The Normal anticoagulant system and risk of placental abruption: protein C, protein S and resistance to activated protein C
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چکیده
منابع مشابه
Activated Protein C Anticoagulant System Dysfunction and Thrombophilia in Asia
Thrombophilia that is common among Caucasians is caused by genetic polymorphisms of coagulation factor V Leiden (R506Q) and prothrombin G20210A. Unlike that in Caucasians, thrombophilia that is common in the Japanese and Chinese involve dysfunction of the activated protein C (APC) anticoagulant system caused by abnormal protein S and protein C molecules. Approximately 50% of Japanese and Chines...
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Activated protein C resistance as an additional risk factor for thrombosis in protein C-deficient families.
Heterozygous protein C deficiency is associated with an increased risk for thrombosis. This association is restricted to a minority of protein C-deficient families, which have been defined as clinically dominant protein C-deficient. In contrast, in the clinically recessive protein C-deficient families, only the homozygous family members are (severely) affected. One possible explanation for this...
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The anticoagulant protein C system regulates the activity of coagulation factors VIIIa and Va, cofactors in the activation of factor X and prothrombin, respectively. Protein C is activated on endothelium by the thrombin-thrombomodulin-EPCR (endothelial protein C receptor) complex. Activated protein C (APC)-mediated cleavages of factors VIIIa and Va occur on negatively charged phospholipid membr...
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ژورنال
عنوان ژورنال: The Journal of Maternal-Fetal & Neonatal Medicine
سال: 2010
ISSN: 1476-7058,1476-4954
DOI: 10.3109/14767051003710284